Extracorporeal apheresis therapy for Alzheimer's disease targeting lipids, stress and inflammation.

Source: Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R. Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation. Mol Psychiatry. 2020 Feb;25(2):275-282. doi: 10.1038/s41380-019-0542-x. Epub 2019 Oct 8. PMID: 31595035.

Alzheimer's disease is a progressive neurological disorder that affects over 40 million people worldwide. Given the limited efficacy of current therapeutic approaches for Alzheimer's disease (AD), an urgent need for effective treatment methods has emerged. In this context, extracorporeal apheresis therapy offers a promising alternative.

New research has highlighted the central role of the metabolic inflammatory process and stress in the development of Alzheimer's disease. Research has shown that overproduction of lipids, combined with oxidative stress and chronic inflammation, can contribute to the development of the disease.

Extracorporeal apheresis therapy, a procedure already successfully used in other medical fields such as the treatment of autoimmune diseases, could remove these harmful factors from the bloodstream. This involves filtering the patient's blood outside the body to remove harmful substances before it is returned to the body.

Current pilot studies of this innovative treatment method show encouraging results, suggesting the potential application of extracorporeal apheresis therapy in the prevention and treatment of Alzheimer's disease. However, extensive research is still needed to fully understand and evaluate the efficacy of this method.

Overall, the current state of research suggests that the treatment of Alzheimer's disease by targeting interventions against metabolic inflammation and stress through extracorporeal apheresis therapy may have a promising future. However, there is an urgent need for further studies to confirm these promising initial observations and to further improve the utility of this new treatment strategy for patients with Alzheimer's disease.

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